Thursday, 8 October 2015

PHARMA QUIZ-BCQ-LAXATIVE

ANSWER: c) Lactulose
                       
Bisacodyl has structurally similarity to phenolphthalein; it is a derivative of triphenylmethane. It is used to relieve constipation especially in neurogenic bowel dysfunction, also preferred to be used before colonoscopy. Neurologic bowel dysfunction is the condition which is characterized by constipation or incontinence in the evacuation of the bowel due to spinal cord injury affecting overall quality of life.

Senna is also used to relieve constipation, it is actually used as non-prescription drug, and it is also used in irritable bowel syndrome and in hemorrhoids.

Magnesium Sulfate is orally when used; it is used as saline laxative.

Lactulose is a semi-synthetic disaccharide, used orally in the treatment of constipation, it takes a long time to produce action that is about eight to twelve hours, and effect is best prominent in two days.

Liquid paraffin is also used to relieve constipation, but it is not occasionally used, as it causes irritation to the anus and also interferes in the absorption of the fat-soluble vitamins.


Bisacodyl and Senna cannot be used for long term period as it causes non-functioning atonic colon, magnesium salts on the other hand are useful for rapid evacuation of the bowel, even magnesium salts and liquid paraffin are not preferred for long term use, and in case of elderly and bedridden the treatment is needed for a long period, so the best option is the use of Lactulose which is a semi-synthetic disaccharide, which can be given for a long time in management of constipation.

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