Saturday, 3 April 2021

MCQ-218

 




Answer: d) a,b & c

Colesevelam, colestipol and colestyramine increases the binding of bile acids in the intestine, interfering with its absorption, as a result of which demand for bile acids increases for which cholesterol is converted to bile acid in the presence of 17 α hydroxylase, this causes increased demand of cholesterol in the liver cells, this increases the activity of HMG-CoA reductase which increases hepatic LDL receptors sensitivity, thus decreases serum LDL cholesterol.


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