Pyridostimine is less powerful and
slower in action than neostigmine but it has longer duration of action. It has
mild gastrointestinal side effects, but antimuscarinic drug is still required
for stomach cramps. The total daily dose of 450 mg should not be exceeded as it
leads to acetylcholine receptor downregulation. Immunosuppressant therapy is
required at a daily dose of 360 mg. it is only available as a tablet, unlike neostigmine
which is available as a tablet and an injection.
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